10
20 30
40 50
60 70
80 90 100 110 120
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I
II II
TEMPLATE
III
III I
structure
(((((
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CAACCCCAA
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Tetrahymena thermophila AUACCCGC----UUAAUUCAU-UCAGAUCUGUAAUAGAACUGUCAUUCAACCCCAAAAAUCUAGUGCU-GAUAUAACCUUCACCAAUUAGGUU----CAAAUAAGUGGU-AAU--GCGGG
Tetrahymena malaccensis AUACCCGC----UUAAUUCAU-UCAGUUCUGUAAUAGAACUGUCAUUCAACCCCAAAAAUCUAGUGCU-GAUAUAACCUUCACCAAUUAGGUU----CAAAUAAGUGGU-AAU--GCGGG
Tetrahymena pyriformis AUACCCGC-----AUAUUCAU-UCAAAUCUGUAAUAGAUUUGUCAUUCAACCCCAAAAAUCUAGUGCA-ACUAAUACCUUCGCCAAUUAGUGU----AUAAUUAAUGGUUCUC--GCGGG
Tetrahymena vorax AUACCCGC-----ACAUUCAC-UCAAAUCUGUAAUAGACUUGUCAUUCAACCCCAAAAAUCUAGUGCA-AAUAUUACCUUCGCCAAUUAGGUA----CAAUUAA-UGGUUCUC--GCGGG
Tetrahymena borealis AUACCCGC-----AAAUUCAU-UCAGGUCUGUAAUAGAUCUGUCAUUCAACCCCAAAAAUCUAGUGCA-AAUAUUACCUUCACCAAUUAGGUA-----UAAUCAAUGGU-AUC--GCGGG
Tetrahymena australis AUACCCGC------AUAUCAU-UCAGACCCUUUAUGGAACUGUCAUUCAACCCCAAAAAUCUAGUGCA-AAUAUUGUCUUAAUUACUUAGGCUAAAAGAAAUAAGUAUU-AAA--GCGGG
Tetrahymena silvana AUACCCGC-----AAAUUCAC-UCAAAUCUGUAAUAGGUUUGUCAUUCAACCCCAAAAAUCUAGUGCA-AAUAUUACUUUCGCCAAUUAGGUA-----UAAUAA-UGGU-AA---GCGGG
Tetrahymena pigmentosa AUACCCGC--------AUCAU-UCAGAUCUAUUAUGGAGCUGUCAUUCAACCCCAAAAAUCUAAUGCA-ACUACUGCCUUAACUAUUUAGGCA--UUAUAAUAAAUAUA-AAA--GCGGG
Tetrahymena hyperangularis AUGCCCGC--------AUCAU-UCAGAUCUAUUAUGGAGCUGUCAUUCAACCCCAAAAAUCUAAUGCA-A-UACUGCCUUAACUAUUUAGGCA--UAAUAAUAAAUAUA-AAA--GCGGG
Tetrahymena capricornis AUACCCGC-----AUUUUCAU-UCAGAUCUUUAAUGGAGCUGUCAUUCAACCCCAAAAAUCUAGUGCA-ACUACUGCCUUAACUACUUAGGCA-----AAAUAAGUCGU-AAA--GCGGG
Tetrahymena hegewishii AAACCCGC-----AUACUCAU-UCAGAUCUGUAAUGGUUCUGUCAUUCAACCCCAAAAAUCUAGUGCU-ACUACUGCCUUAACUACUUAGGCA-----AAAUAAGUUGG-AAA--GCGGG
Glaucoma chattoni A--CCUCCUG-GUAGAUCCAU-UCAGGAUUAAUGAAAUCCUGUCAUUCAACCCCAAAAAUCUUGUCAA-AUUAUUGCCU-CGUCUUUUGGGCA----ACAACAAAAGUC-ACGCAGGAGG
Tetrahymena paravorax AAUCCCGCUAUUGCAUUCCAUUUCGA---------------GUCAUUCAACCCCAAAAUUCUAGUACACACUAAAGCUU---GCCUUUGGGCA-----UAUCAGGGGC------AGCGGG
130
140
150
160
170
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IV
IV
structure
) ((((((((((
((((((((( ))))) ))))) ))))))
Tetrahymena thermophila -ACAA-AAGACUAUCGACAUUUGAUAC-ACUAUUUAUCA-AUGGA-UGUCUUAUUU-U
Tetrahymena malaccensis -ACAA-AAGACUAUCGACAUUUGAUAC-ACUAUUUAUCA-AUGGA-UGUCUUAUUU-U
Tetrahymena pyriformis -ACAA-AAGACUAUCGACAUUUGAUAC-ACUAUUUAUCA-AUGGA-UGUCUUAUUU-U
Tetrahymena vorax -ACAA-AAGACUAUCGACAUUUGAUAC-AUUAUUUAUCA-AUGGA-UGUCUUAUUU-U
Tetrahymena borealis -ACAA-AAGACUAUCGACAUUUGGUAC-ACUAUUUAUCA-AUGGA-UGUCUUAUUU-U
Tetrahymena australis -ACAA---GGC-AUCGACAUUUGAUACAAAUAUUGAUCA-AUGGA-UGUCUUAUUU-U
Tetrahymena silvana -AC---AAGAC--UCGACAUUUGAUAC-ACUAUUUAUCA-AUGGA-UGUCUU-UUU-U
Tetrahymena pigmentosa -AC----GGAC-AUCGACAUUGGAUCCUAAUAUUGACCA-AUGGA-UGUCUU-UUUUU
Tetrahymena hyperangularis -AC----GGAC-AUCGACAUUGGAUCCUAAUAUUGACCA-AUGGA-UGUCUU-UUUUU
Tetrahymena capricornis -AC---AAGGC-AUCGACAUUUGAUACAAAUAUUGAUCA-AUGGA-UAUCUUAUUUUU
Tetrahymena hegewishii -AC---AAGGC-AUCGACAUUUGAUACAAAUAUUGAUCA-AUGGA-UGUCUUAUUU-U
Glaucoma chattoni -UUCA--GGUG-UUCGACGUAAGAUAC-ACUAUUUAUCUUAUGGAAUGCCAAGUUU-U
Tetrahymena paravorax AGAAUUUAGAAUUUCGACAUGUGGUAC-ACUAUUUAUCUCAUGGAGAUUCUAAUUU-U